Polynucleotide Injections

Procedure time – 45-60 minutes

Back to work – 30 mins – 24 hrs (depending on area treated & individual response)

Anaesthetic - topical

Used to treat - lines & wrinkles, scarring, sun damage, sagging & ageing skin, dull & dry skin, under eye dark circles, puffiness, hollows

Results – up to 3 months

Duration of results – 6-12 months

Risks & Complications - discolouration, inflammation, itching, nodules, bruising, swelling, infection, allergic reaction

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Here at Mango Aesthetics, we offer Vitaran polynucleotide injections, a skin injectable which contains polynucleotide sodium derived from highly purified fragments of trout DNA. The injectable is administered into areas of the face, neck, décolletage and hands in order to reduce the signs of ageing by improving the appearance of fine lines and wrinkles. Vitaran has anti-inflammatory properties and activates the skin’s production of collagen, elastin and hyaluronic acid, which hydrates the skin. As a result, the skin is rejuvenated, it’s cell turnover is regulated and it’s natural barrier is repaired. In addition, Vitaran is capable of facilitating the remodelling of areas of the skin which have high fibrous content such as scarring.

Polynucleotides are the ‘Gold Standard’ for:

Boosting collagen production and elastin for an overall rejuvenation of the under eyes, face, neck, décolletage and hands.
Enhancing skin hydration, circulation and overall skin quality.
Eyes: Polynucleotides reduce dark under-eye circles and smooth crow’s feet, fine lines, hollows and puffiness beneath the eyes.
Skin on forehead: Polynucleotides smooth fine lines, encourage glowing skin and can be used as an alternative to popular anti-wrinkle injections.
Skin on cheeks: Polynucleotides smooth folds and lines, tightening and lifting cheeks and hydrating skin.
Smokers lines and lines around the mouth/chin: Polynucleotides smooth lines around the mouth without plumping or adding volume.
Jawline: Polynucleotides help tighten and define jawline.
Neck: Treat crepey-looking skin and fine lines on the neck.
Hands: Smooths and improves texture and improves elasticity.

Treatments & Prices

Under eyes:

1 Treatment: £125
2 Treatments: £250
3 Treatments: £337*

Face/neck/décolletage/hands:

1 Treatment: £180
2 Treatments: £360
3 Treatments: £486*
*10% discount on course of 3 treatments

Trusted and established nurse led aesthetic clinic.

Safety is the priority – Our polynucleotide treatments are performed by our highly experienced Aesthetic Nurse who is NMC registered. Our clinic adheres to the highest safety and well-being standards.

Premium injectable products – We always use the premium polynucleotide product available as we firmly believe you get what you pay for.

Injection procedure – We can perform polynucleotide treatment either with a needle (meso technique) or using a cannula which is a minimal-bruising injection technique to minimise your downtime post-treatment.

Aftercare – We offer excellent client care and follow-up. If you were to experience any complications related to your polynucleotide treatment, you would be in the safest hands.

Results – Our highly reputable Aesthetic Nurse is known to deliver exceptional results.
Consultation - During your initial consultation, our expert Aesthetic Nurse will take time to understand your concerns, expectations, and desired outcomes and advise if polynucleotides treatment is the best option for you. Your areas of concern will be assessed to determine the best course of treatment.

Treatment – You can have your first polynucleotide treatment on the day of your initial consultation or you can book a treatment for a time of your convenience. A course of 3 polynucleotide treatments delivered 2-4 weeks apart is normally recommended to achieve optimum results.

Polynucleotide Injections – Needle or cannula can be used to carefully inject the polynucleotides solution. Injections are strategically placed to stimulate collagen production, improve skin texture, and reduce the appearance of lines and wrinkles.

Post-Treatment Care and Recovery – Recovery from polynucleotide treatment may take several days to recover from due to the presence of blebs from treatment and possibility for bruising.

Follow-Up and Results – Your treatment will be performed every 2-4 weeks (normally 3 treatments in total). We then advise a top-up single treatment every 6-12 months to sustain your result. While some initial results may be visible soon after the treatment, the full benefits of polynucleotide rejuvenation tend to be seen several months after completing the treatment.
Results typically last 6-9 months. A single top-up session is then recommended to sustain the result.

What is the difference between Polynucleotides treatment for under eyes and traditional under eye filler/Tear Trough Filler?

Polynucleotides (PN) is a very thin water-like substance which improves skin quality whereas traditional under eye filler/Tear Trough filler is hyaluronic acid which is a much more viscous substance and is designed to fill hollows under eyes.

Polynucleotide treatment works with the body’s DNA to promote cellular regeneration. This innovative treatment stimulates collagen and elastin production, which are essential proteins for maintaining the skin’s structure and elasticity and works to treat fine lines and dark eye circles.

There has been a recent rise in searches for ‘under eye fillers gone wrong’. This is due to the fact that hyaluronic acid-based fillers in tear trough filler can sometimes make the under-eye area appear puffier, as hyaluronic acid attracts water and can migrate. Polynucleotide injections will not ‘fill’ the under eye area and will not cause puffiness or migration of the product. The focus is on achieving natural-looking results that enhance the skin’s elasticity, reduce pigmentation and minimise fine lines and wrinkles.
This depends on how your under-eye looks and what you wish to treat. If your concern is hollows only and you are not prone to puffiness (eye bags) under eyes then tear trough filler is the best option.

If you are concerned with fine lines / crepey skin under the eye and / or dark circles OR you’re prone to eye puffiness (eye bags) then polynucleotides are the best option.

Tear trough filler can sometimes make the under-eye area appear puffier, as hyaluronic acid attracts water and can migrate. Polynucleotide injections will not ‘fill’ the under eye area and will not cause puffiness or migration of the product.
Natural-looking results: Polynucleotides gradually improve skin quality, avoiding potential overfilling and a “done” look.

Better for skin health: Polynucleotides stimulate collagen and elastin production, leading to long-term improvement in skin quality.

Fewer side effects: Polynucleotides are generally considered less risky than fillers, with minimal downtime and rare allergic reactions.

Suitable for sensitive skin: Polynucleotides may be preferable for those with thin or sensitive skin.

Under eye fillers are a more suitable option for:

Significant volume loss: Fillers can effectively address very deep tear troughs and hollowness that polynucleotides wouldn’t.

Immediate results: Fillers offer instant correction for those seeking a quick turnaround.

Ultimately, the best choice for you depends on your individual concerns and desired outcome. Consulting our highly qualified Aesthetic Nurse is crucial to understand your options and make an informed decision based on your specific needs and goals.
Polynucleotides offer a number of benefits:

Minimise Dark Circles – One of the primary concerns for many individuals is the presence of dark circles under the eyes. Polynucleotide treatment reduces the pigmentation and discoloration that contribute to the appearance of these dark circles. Impressively, results show that polynucleotide injections improves under-eye brightness in individuals by over 32% in as little as 4 weeks.

Improves Skin Elasticity – Loss of skin elasticity is a common sign of ageing, leading to the formation of fine lines and wrinkles. Polynucleotide treatment promotes greater skin elasticity, restoring a more youthful and supple appearance to the under-eye area. Polynucleotides are proven to increase skin elasticity by approximately 22 % within just a few weeks.

Reduces the look of under-eye hollows – Deep tear troughs can create a tired and sunken look. While polynucleotides do not fill out these hollows like traditional filler, the treatment does help to subtly reduce the appearance of these under-eye depressions by plumping and rejuvenating the skin in this area.

Increases Cell Turnover – Cell turnover is essential for maintaining healthy and vibrant skin. Polynucleotide treatment increases cell turnover, resulting in a fresher and more rejuvenated under-eye area.

Protects Against Free Radical Damage – Free radicals are unstable molecules that can damage the skin and accelerate the aging process. Polynucleotide injections possess antioxidant properties that help protect the under-eye area from free radical damage, promoting overall skin health.

Hydrated Under Eyes – Hyaluronic acid is a natural substance found in the skin that helps retain moisture and maintain hydration. Polynucleotides stimulates higher hyaluronic acid synthesis, ensuring that the under-eye area remains hydrated and plump.

Minimises Fine Lines and Wrinkles – Fine lines and wrinkles can be a source of frustration for many individuals. Polynucleotide treatment stimulates collagen and elastin production. The improved skin elasticity reduces the appearance of fine lines and wrinkles around the eyes, helping to promote a smoother under-eye area

Improved Skin Texture – Polynucleotides have the ability to improve skin texture, creating a smoother and more refined under-eye area. This treatment can help reduce the appearance of roughness and unevenness, resulting in a refreshed and youthful look.
Polynucleotides are created from salmon DNA using a proprietary process. There is an extraction and purification process which ensures the safety and compatibility of the product for use in human skin.
Both polynucleotide and skin booster treatments are popular injectable options for skin rejuvenation, but they have key differences in their composition, mechanisms of action, and suitability for different concerns. Polynucleotides and skin boosters are made up of different ingredients and work in different ways:

Polynucleotides are DNA extracts which is a form of “regenerative medicine”. It is a water-based substance that stimulates your own body’s collagen and elastin production to create healthier, younger-looking, rejuvenated skin by working on a cellular level. It does not contain hyaluronic acid, so does not draw in water or give much plumping of the skin like skin boosters do.

Skin boosters contain hyaluronic acid which is injected into the skin to give hydration and plumping, but it does not regenerate the skin on a cellular level in the way polynucleotides do. Skin boosters are a thicker (more viscous product) which acts like a ‘honey’, spreading under the skin and drawing in water to give a more plumped appearance than polynucleotides tend to.

Polynucleotides can be used around eyes and on forehead whereas skin boosters cannot. Both polynucleotides and skin boosters are suitable for use on cheeks, neck, décolletage and hands

Both polynucleotides and skin boosters require a course of initial treatments (minimum of 2) then a single treatment top up every 6-9 months.
When polynucleotides are injected into the skin, they work by stimulating the body’s natural repair mechanisms, repairing damaged cells, boosting collagen and elastin production. They also possess anti-inflammatory properties, so can reduce redness and swelling, making them useful for treating conditions like acne and rosacea. Polynucleotides increase the skin’s ability to retain moisture, resulting in a more hydrated complexion, so they are excellent for treating dry / dehydrated skin. They can accelerate the wound healing process, helping to minimise recovery from ablative procedures like laser treatments or micro-needling, and can be used to reduce the appearance of stretch marks and acne scarring. Our Aesthetic Nurse uses polynucleotides with subscision to treat stubborn acne scarring and has had good results with this.
Typically 2-3 polynucleotide treatments are required, each 2-4 weeks apart.
Polynucleotide treatment involves injections and the pH of the product means it is more “stingy” than some other injectable treatments. Based on the area being treated & the method (cannula or needle) our Aesthetic Nurse will use a topical numbing cream to minimise discomfort.
Most people will be suitable for polynucleotide treatment. If you are pregnant or breast-feeding this treatment is not suitable. If you are vegan this treatment is not suitable as it is an animal-derived product.
The polynucleotide treatment can be performed with either a cannula or a needle. Recovery from needle takes longer than from cannula due to the appearance of blebs on the skin. Recovery from polynucleotide treatment with needle is 1-2 days. Recovery from polynucleotide treatment with cannula is typically 12- 24 hours.